The Laboratory for Bone and Muscle Cell Biology studies the regulation of differentiation and activity of cells of the musculoskeletal system.

We are interested in understanding regulation of the behaviour of bone, cartilage and muscle cells during development, regeneration and pathology, with particular emphasis on the roles of proteases and extracellular matrix.

Current projects

  • The role of protease-activated receptors in the pathophysiology of muscular dystrophy, periodontitis-associated bone loss and prostate cancer metastasis to bone
  • Regulation of mesenchymal stem cell fate by protease-activated receptors
  • The role of osteopontin in muscle regeneration
  • Morphological diversity of chondrocytes in growth cartilage
  • Bone health in dairy animals
  • Bone microstructure and turnover in athletic horses (as part of the Equine Orthopaedic Research Group)

Research Group Contacts

Professor Eleanor Mackie
Title: Professor in Veterinary Preclinical Sciences
Email: ejmackie@unimelb.edu.au 
Ph: +61 3 8344 7360
Faculty of Veterinary and Agricultural Sciences - University of Melbourne

Dr Charles Pagel
Title: Senior Lecturer (Agricultural Molecular Sciences)
Email: cpagel@unimelb.edu.au 
Ph: +61 3 8344 7362
Faculty of Veterinary and Agricultural Sciences - University of Melbourne

Researchers

Mrs Liliana Tatarczuch - Electron Microscopist
Dr Babatunde Ayodele – Research Fellow (Musculoskeletal Biology)

Research Students

Aisha Tarar
Megan Thomas
Mohammadreza Sanaei

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